Will SharePoint Server 2010 Put (fill in any given ISV here) Out Of Business? Nothing’s Impossible
Let’s get the easy part out of the way, the specific case of Nintex… Microsoft Office SharePoint Server 2007 shipped in November 2006.  Work on what we now call Microsoft SharePoint Server 2010 began months before that date.  I didn’t leave Microsoft until the end of May 2008.  Make no mistake: the day I left Microsoft, I put up a “Chinese wall” around part of my own head, and I continue to regard my ex-employee NDA as a sacred trust.  But ask yourself:  would Fitz join a company whose products would be rendered obsolete by what he knew was being planned for “Office 14”?  (Hint: no.)